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Continuous estrogen/progestin therapy in menopause.

S G Prough1, S Aksel, R H Wiebe

  • 1Department of Obstetrics and Gynecology, University of South Alabama, Mobile 36688.

American Journal of Obstetrics and Gynecology
|December 1, 1987
PubMed
Summary
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Continuous hormone therapy with conjugated equine estrogens and medroxyprogesterone acetate effectively reduced menopausal symptoms and vaginal bleeding. This regimen showed no significant short-term impact on blood pressure or serum lipid levels in postmenopausal women.

Area of Science:

  • Endocrinology
  • Gynecology
  • Pharmacology

Background:

  • Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
  • Different HRT regimens exist, including continuous and cyclic administration of estrogens and progestins.
  • Evaluating the safety and efficacy of various HRT protocols is crucial for patient care.

Purpose of the Study:

  • To compare the effects of continuous versus cyclic conjugated equine estrogens plus medroxyprogesterone acetate on postmenopausal women.
  • To assess changes in vaginal bleeding, endometrial histology, menopausal symptoms, blood pressure, and serum lipid profiles.

Main Methods:

  • A pilot study involving 26 postmenopausal women divided into two groups.
  • Group I (N=16) received continuous conjugated equine estrogens and medroxyprogesterone acetate.

Related Experiment Videos

  • Group II (N=10) received cyclic conjugated equine estrogen plus medroxyprogesterone acetate over 9 months.

    • Main Results:

    • Continuous therapy (Group I) resulted in inactive endometrium and virtually eliminated vaginal bleeding.
    • Cyclic therapy (Group II) showed one case of proliferative endometrium and 80% of patients experienced cyclic menses.
    • Neither regimen significantly altered blood pressure, total cholesterol, HDL, LDL, or triglyceride levels.

    Conclusions:

    • Continuous conjugated equine estrogen plus medroxyprogesterone acetate is a satisfactory HRT option for postmenopausal women.
    • This continuous regimen effectively reduces menopausal symptoms and eliminates cyclic bleeding without adverse short-term effects on lipids or blood pressure.