Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology
Camila Lopez-Crisosto1, Christian Pennanen1, Cesar Vasquez-Trincado1
1Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas &Facultad de Medicina, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile.
Nature Reviews. Cardiology
|March 10, 2017
Summary
Mitochondria and the sarco/endoplasmic reticulum communicate to manage calcium and energy in muscle cells. Dysfunction in this communication contributes to cardiovascular diseases like heart failure.
Area of Science:
- Cardiovascular Physiology
- Mitochondrial Biology
- Cellular Metabolism
Background:
- Cardiomyocytes and vascular smooth muscle cells rely on mitochondria for energy and calcium buffering.
- Mitochondrial metabolism influences vascular smooth muscle cell growth, while calcium regulates vascular tone.
- Proper communication between mitochondria and the sarco/endoplasmic reticulum is vital for calcium homeostasis and muscle cell function.
Purpose of the Study:
- To review the physiological roles of sarco/endoplasmic reticulum-mitochondria communication in cardiac and vascular muscle.
- To explore how disruptions in this communication contribute to cardiovascular disease pathogenesis.
Main Methods:
- This review synthesizes existing research and evidence from scientific literature.
- Focuses on the physical and functional interactions between mitochondria and the sarco/endoplasmic reticulum.
Main Results:
- Mitochondrial dysfunction is linked to myocardial damage and altered vascular smooth muscle proliferation.
- Sarco/endoplasmic reticulum-mitochondria coupling and mitochondrial dynamics are critical for calcium transfer and homeostasis.
- Perturbations in these processes are implicated in diseases such as coronary artery disease, heart failure, and pulmonary arterial hypertension.
Conclusions:
- Sarco/endoplasmic reticulum-mitochondria communication and mitochondrial dynamics are key factors in cardiovascular health.
- Dysregulation of these pathways plays a significant role in the development of major cardiovascular disorders.
- Understanding these interactions offers insights into potential therapeutic targets for cardiovascular diseases.
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