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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Paraoxonase 1 - an Update of the Antioxidant Properties of High- Density Lipoproteins
Bogdan Nicolae Manolescu1, Carmina Busu2, Daniela Badita3
1Department of Organic Chemistry "C.D. Nenitescu", Faculty of Applied Chemistry and Science of Materials, Polytechnic University, Bucharest, Romania.
Abstract:
Paraoxonase 1 (PON1) belongs to a family of enzymes with related functions, being the best studied member. PON1 is a HDL-associated protein of which function is to protect LDL particles from oxidative modifications. The status of PON1 is influenced by different genetic, life style and dietary factors. This short review is aimed to present some new aspects regarding the antioxidant properties of PON1 with emphasis on the influence exerted by different factors. Also, a special attention is paid to the relationship between PON1 and low- and high-density lipoproteins in the context of atherosclerosis which affects the endothelial cells.
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