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Reactive Retinal Astrocytic Tumor (Focal Nodular Gliosis): A Case Report
Lauren E Hudson1, Pia R Mendoza2, Jiong Yan1
1Department of Ophthalmology, BT 428 Emory Eye Center, Atlanta, Ga., USA.
Purpose:
To report the clinical and histopathological findings of a reactive retinal astrocytic tumor (RRAT) that progressed to massive retinal gliosis.
Observations:
The patient presented with an elevated, white-yellow retinal mass and extensive retinal exudation in the left eye. Progressive enlargement of the mass and proliferative vitreoretinopathy eventually led to phthisis bulbi and enucleation. Histologically, the mass showed a predominant astrocytic component with intense glial fibrillary acidic protein staining, hyperplasia, fibrous metaplasia, and osseous metaplasia of the retinal pigment epithelium. The Ki-67 proliferative index was <5%, and few scattered vascular channels were observed.
Conclusions And Importance:
These findings show that this tumor is the result of a reactive glial process rather than of neoplastic vascular proliferation. Massive retinal gliosis probably represents the advanced stage of RRAT.
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