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Bronchial carcinoid tumor with amyloid stroma
N Al-Kaisi1, F W Abdul-Karim, G Mendelsohn
1Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106.
Archives of Pathology & Laboratory Medicine
|February 1, 1988
Summary
This study presents a unique atypical bronchial carcinoid tumor with abundant stromal amyloid. It discusses the differential diagnosis from other amyloid-producing neuroendocrine tumors.
Area of Science:
- Pulmonary Pathology
- Oncology
- Cell Biology
Background:
- Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms.
- Amyloid deposition can occur in various tumors, including some NETs.
- Atypical bronchial carcinoid tumors represent a specific subtype of lung NETs.
Observation:
- A rare case of atypical bronchial carcinoid tumor exhibiting extensive stromal amyloid deposition is described.
- Histopathologic, immunohistochemical, and ultrastructural analyses were performed.
- The tumor morphology and amyloid characteristics were meticulously documented.
Findings:
- The presented case is unique due to the significant amount of stromal amyloid within the atypical bronchial carcinoid.
- Immunohistochemical staining confirmed the neuroendocrine nature of the tumor cells and characterized the amyloid.
- Ultrastructural examination provided insights into the amyloid fibril formation.
Implications:
- This case expands the understanding of tumor-associated amyloidosis in pulmonary neuroendocrine neoplasms.
- It highlights the importance of considering amyloid production in the differential diagnosis of atypical bronchial carcinoids.
- Further research may elucidate the mechanisms of amyloidogenesis in these specific tumors.