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Heyde syndrome revisited: anaemia and aortic stenosis

Catherina Tjahjadi1, Yong Wee1, Karen Hay2

  • 1Department of Cardiology, Prince Charles Hospital, Brisbane, Queensland, Australia.

Internal Medicine Journal
|March 10, 2017
PubMed

Insights

Patients with aortic stenosis (AS) have a higher prevalence of anemia compared to those undergoing coronary artery bypass grafting (CABG). This finding suggests Heyde syndrome may be more common in AS patients than previously thought.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • The link between anemia and aortic stenosis (AS) is known but poorly documented.
  • Prevalence data for this association are scarce.

Purpose of the Study:

  • To compare the prevalence of anemia in adults with AS against a control group undergoing coronary artery bypass grafting (CABG).

Main Methods:

  • Retrospective cohort study.
  • Compared pre-procedural hemoglobin levels in 1537 adults undergoing aortic valve replacement (AVR) for AS with 8025 patients undergoing CABG.
  • Hypothesized higher anemia prevalence in AS patients.

Main Results:

  • Anemia prevalence was 30.1% in the AVR group versus 16.2% in the CABG group.
  • Mean hemoglobin was lower in AVR patients (132 g/L) than CABG patients (138 g/L).
  • Multivariable analysis showed significant variations in hemoglobin by treatment group, gender, and age.

Conclusions:

  • Anemia is significantly more prevalent in patients with AS compared to a CABG cohort.
  • This suggests Heyde syndrome may be more common than appreciated and warrants consideration in AS patients with anemia.
Abstract

Keywords:
anaemiaaortic valve stenosiscoronary artery bypasshaemoglobin

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