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Updated: Mar 6, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Strategies to optimize the use of antibiotics in hospitals]
J Gómez1, C Bonillo, L H Navarro
1Joaquín Gómez Gómez Hospital Clínico Universitario Virgen Arrixaca. IMIB-Arrixaca, Murcia. Carretera Madrid-Cartagena s.n. 30120 El Palmar. Murcia. España
Abstract:
The inadequate use of antibiotics is a clinical reality we are faced with day by day. The great peculiarity of this group of drugs is the influence they have not only on the patients and at the time of their use, but also of future infections and the general population, by favoring alterations in the resistance patterns of the bacterial microflora that colonize people. It is our obligation as experts in infectious diseases to work on improving the use of antimicrobials.
Insights
Inadequate antibiotic use impacts patients and the public by promoting bacterial resistance. Experts must improve antimicrobial stewardship to combat this growing threat.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Public Health
Background:
- Inadequate antibiotic use is a prevalent clinical issue with far-reaching consequences.
- Antibiotics affect not only individual patients but also future infections and the broader population.
- This practice contributes to the alteration of bacterial microflora resistance patterns.
Purpose of the Study:
- To highlight the critical need for improved antimicrobial use.
- To emphasize the role of infectious disease experts in antimicrobial stewardship.
- To address the public health implications of antibiotic resistance.
Main Methods:
- This study is a clinical observation and expert opinion piece.
- It reviews the impact of current antibiotic prescribing practices.
- It discusses the mechanisms by which antibiotic use affects bacterial resistance.
Main Results:
- Suboptimal antibiotic administration is a daily clinical challenge.
- Altered bacterial resistance patterns are a direct consequence of antibiotic misuse.
- The effects of antibiotic use extend beyond the individual patient to the general population.
Conclusions:
- Improving antimicrobial use is an ethical obligation for infectious disease specialists.
- Effective antimicrobial stewardship is crucial to mitigate the rise of antibiotic resistance.
- Addressing inadequate antibiotic use is essential for public health and future patient care.
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