Related Experiment Videos
Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina
J E Brown1, D C Watkins, C C Malbon
1Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63110.
The Biochemical Journal
|October 15, 1987
Abstract:
Illumination induced an increase in inositol polyphosphates, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate, in the photoreceptors of the squid, Loligo pealei. There was a concomitant decrease in phosphatidylinositol 4,5-bisphosphate, but no light-induced change in any other phosphoinositide. None of these stimulus-induced changes were altered by treatment in vivo with pertussis toxin, which ADP-ribosylated a Mr-39000-peptide. These findings support the hypothesis that inositol 1,4,5-trisphosphate participates as either a messenger or a modulator in transduction in invertebrate photoreceptors.