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Updated: Mar 6, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

Renal cell carcinoma.

James J Hsieh¹, Mark P Purdue², Sabina Signoretti³

¹Molecular Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8069, St. Louis, Missouri 63110, USA.

Nature Reviews. Disease Primers

|March 10, 2017

Summary

This summary is machine-generated.

Renal cell carcinoma (RCC) is a kidney cancer with many subtypes, most commonly clear cell RCC (ccRCC). Advances in targeted therapies and immunotherapies have improved metastatic RCC treatment, offering new hope.

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Area of Science:

Oncology
Genetics
Pharmacology

Background:

Renal cell carcinoma (RCC) originates from kidney epithelium, comprising over 90% of kidney cancers.
Clear cell RCC (ccRCC) is the most prevalent subtype and responsible for most cancer deaths.
Intra-tumour heterogeneity and epigenetic alterations are increasingly recognized for their clinical relevance.

Purpose of the Study:

To provide an overview of renal cell carcinoma (RCC) biology, focusing on clear cell RCC (ccRCC).
To update on recent therapeutic advances for metastatic RCC.
To outline future directions in RCC research and treatment.

Main Methods:

Review of current scientific literature on RCC biology and treatment.
Analysis of recent clinical trial data and drug approvals.
Synthesis of information to complement existing clinical guidelines.

Main Results:

RCC encompasses diverse histological and molecular subtypes, with ccRCC being the most common.
Significant progress in metastatic RCC treatment includes targeted agents (VEGF/VEGFR inhibitors, mTORC1 inhibitors) and immunotherapies.
Newer agents like cabozantinib, lenvatinib, and nivolumab expand treatment options.

Conclusions:

While localized RCC is manageable with surgery, metastatic RCC requires advanced systemic therapies.
The evolving landscape of RCC treatment offers improved outcomes for patients.
Continued research into RCC biology and novel therapeutic strategies is crucial for future progress.