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A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
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A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex
1University Grenoble Alpes, DPM CNRS UMR 5063, F-38041 Grenoble, France. eric.peyrin@univ-grenoble-alpes.fr valerie.guieu@univ-grenoble-alpes.fr.
Nanoscale
|March 10, 2017
Abstract:
Herein, we report a novel approach for the design of a colorimetric aptasensor based on functionalized gold nanoparticle probes. This approach relies on the conjugation of nanoparticles by two functional DNA and RNA hairpins that engage specific kissing (loop-loop) interactions in response to the addition of a small analyte ligand, leading to particle aggregation and then red-to-purple colour change of the colloidal solution.

