Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

12.5K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
12.5K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

55
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
55
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

76
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
76
Epigenetic Regulation01:46

Epigenetic Regulation

34.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.1K
Epigenetic Regulation01:37

Epigenetic Regulation

4.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.0K
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

98
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
98

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abalone-derived dermatopontin and its RFK-containing peptide promote osteogenesis via TGF-β/Smad signaling pathway.

International journal of biological macromolecules·2026
Same author

MIF-MAPMS: Enhancing identification of myelin autoantigenic peptides in multiple sclerosis through multimodal information fusion.

Protein science : a publication of the Protein Society·2026
Same author

RGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Inhibition of calpain-mediated BAX cleavage attenuates Japanese encephalitis virus-induced apoptosis in SH-SY5Y neuroblastoma cells.

Virology journal·2026
Same author

NToxSEM: Enhancing prediction of neurotoxic peptides and neurotoxins using a stacked ensemble-based multimodal framework.

Protein science : a publication of the Protein Society·2026
Same author

Molecular Mechanisms and Network Pharmacology Revealing Therapeutic Potential of Acetamidosulfonamides against Parkinsonian Model.

ACS omega·2026

Related Experiment Video

Updated: Mar 6, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.0K

Exploring the epigenetic drug discovery landscape.

Veda Prachayasittikul1, Philip Prathipati2, Reny Pratiwi1

  • 1a Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology , Mahidol University , Bangkok , Thailand.

Expert Opinion on Drug Discovery
|March 10, 2017
PubMed
Summary

Epigenetic modifications influence diseases, and targeting these pathways offers therapeutic potential. This review explores epigenomics in drug discovery, including targets, approved drugs, and repurposing strategies.

Keywords:
Epigenomicsbioinformaticscheminformaticschemogenomicsdrug discoverydrugsepigeneticsproteochemometrics

More Related Videos

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.0K
Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP
09:26

Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP

Published on: January 20, 2016

10.9K

Related Experiment Videos

Last Updated: Mar 6, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.0K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.0K
Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP
09:26

Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP

Published on: January 20, 2016

10.9K

Area of Science:

  • Epigenetics and Drug Discovery

Background:

  • Epigenetic modifications are linked to various diseases.
  • Modulating epigenetic systems presents a significant therapeutic strategy in drug discovery.

Purpose of the Study:

  • To survey the concepts and drug discovery aspects of epigenomics.
  • To review factors influencing epigenetics, related diseases, and druggable epigenetic targets.
  • To cover existing FDA-approved drugs and explore drug repurposing for epigenetic targets.

Main Methods:

  • Literature review and survey of epigenomics concepts.
  • Analysis of epigenetic enzymes as drug targets.
  • Examination of existing pharmacological agents and drug repurposing strategies.

Main Results:

  • Identified key factors influencing epigenetics and associated diseases.
  • Highlighted epigenetic enzymes as druggable targets, including approved drugs.
  • Discussed drug repurposing as a rapid discovery method for epigenetic modulators.

Conclusions:

  • Targeting epigenetic modifiers is a promising therapeutic route.
  • Some epigenetic targets remain understudied, presenting challenges for drug development.
  • Future research holds potential for novel drugs to treat complex human diseases.