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Updated: Mar 6, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and cytotoxic activity of two steroids: icogenin aglycone analogs
Yu-Yao Guan1, Shu-Zhen Li1, Ping-Sheng Lei2
1a Pharmacy Department , Traffic Hospital of Shandong Province , Jinan 250031 , China.
Abstract:
During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50 = 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell lines and compound 6 (IC50 = 2.40-9.05 μM) showed potential antitumor activities against HELA, BGC-823, KB, A549, HCT-8 cell lines.
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