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Related Experiment Video

Updated: Mar 6, 2026

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

Published on: June 21, 2018

Association between sedentary behavior and normal-range lactate dehydrogenase activity.

Meghan K Edwards¹, Samuel L Buckner², Jeremy P Loenneke²

¹a Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management , The University of Mississippi , University , MS , USA.

Postgraduate Medicine

|March 10, 2017

Summary

This summary is machine-generated.

Sedentary behavior is not linked to normal lactate dehydrogenase (LDH) activity levels, unlike physical activity. This finding suggests that reducing sedentary time may not directly impact normal LDH levels independently of exercise.

Keywords:

Accelerometry NHANES epidemiology

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Area of Science:

Cardiovascular Health
Biomarkers
Physical Activity Research

Background:

Lactate dehydrogenase (LDH) activity within the normal range may mediate the relationship between physical activity and cardiovascular disease risk.
Sedentary behavior is increasingly recognized for its detrimental health effects, independent of physical activity levels.

Purpose of the Study:

To investigate the association between sedentary behavior and normal-range LDH activity.
To determine if this association persists independently of physical activity levels.

Main Methods:

Analysis of data from 2,087 adults (40-79 years) from the 2003-2006 NHANES.
Measurement of LDH activity via blood samples and assessment of physical activity and sedentary behavior using accelerometry.
Inclusion criteria required participants to have normal-range LDH activity (105-333 IU/L).

Main Results:

Initially, sedentary behavior showed an inverse association with normal-range LDH activity when physical activity was not considered.
After controlling for physical activity and other covariates, this association between sedentary behavior and normal-range LDH activity disappeared.
No significant association was found between sedentary behavior and normal-range LDH activity in the fully adjusted model.

Conclusions:

Sedentary behavior is not independently associated with normal-range LDH activity.
Physical activity, rather than sedentary behavior, appears to be the relevant factor concerning normal-range LDH activity.
These findings highlight the distinct roles of physical activity and sedentary behavior in relation to specific biomarkers.