Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function in trophoblastic disease.

M Lemon1, B R Bevan, T C Li

  • 1Department of Endocrinology, Jessop Hospital for Women, Sheffield.

British Journal of Obstetrics and Gynaecology
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of five-year outcomes and risk factors for insufficient weight loss after laparoscopic sleeve gastrectomy in obese patients].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2026
Same author

Effectiveness and safety of time-lapse imaging for in vitro fertilisation: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Effect of Wuzi Yanzong on semen quality in subfertile men: a double-blind, randomised, placebo-controlled trial (abridged secondary publication).

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Semen metagenomics and spent culture media in patients undergoing conventional in vitro fertilisation: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Reproductive Implications and Management of Congenital Uterine Anomalies: Scientific Impact Paper No. 62.

BJOG : an international journal of obstetrics and gynaecology·2025
Same author

Advanced Methods for Analyzing in-Situ Observations of Magnetic Reconnection.

Space science reviews·2024
Same journal

Livial: an economic appraisal.

British journal of obstetrics and gynaecology·2000
Same journal

Livial: a review of clinical studies.

British journal of obstetrics and gynaecology·2000
Same journal

Place of birth and shoulder dystocia.

British journal of obstetrics and gynaecology·1999
Same journal

The value of the negative predictive values.

British journal of obstetrics and gynaecology·1999
Same journal

Splenectomy during pregnancy: an option in treatment of autoimmune thrombocytopenic purpura.

British journal of obstetrics and gynaecology·1999
Same journal

Third trimester abortion: is compassion enough?

British journal of obstetrics and gynaecology·1999
See all related articles

Human chorionic gonadotrophin (hCG) and thyroid stimulating hormone (TSH) showed a strong correlation in patients with trophoblastic disease. Thyroid hormone levels remained largely unaffected by elevated hCG or TSH, except at very high hCG concentrations.

Area of Science:

  • Endocrinology
  • Oncology
  • Reproductive Biology

Background:

  • Chemotherapy for trophoblastic disease can alter hormone levels.
  • Human chorionic gonadotrophin (hCG) is a key marker in trophoblastic disease.
  • Thyroid function can be influenced by hormonal changes.

Purpose of the Study:

  • To investigate the relationship between hCG levels and thyroid function in patients undergoing chemotherapy for trophoblastic disease.
  • To assess the impact of elevated hCG and thyroid stimulating hormone (TSH) on thyroid hormone concentrations.

Main Methods:

  • Monitoring of hCG levels and thyroid function in 44 patients.
  • Radioimmunoassay (RIA) used for hormone concentration measurements.
  • Analysis of correlations between hCG, TSH, and thyroid hormone levels.

Related Experiment Videos

Main Results:

  • A strong correlation was observed between hCG and TSH concentrations.
  • This correlation is likely due to cross-reactivity between hCG and the anti-TSH antibody.
  • Thyroid hormone levels were generally unaffected, except when hCG exceeded 100,000 i.u./l.

Conclusions:

  • The study highlights potential assay interference in monitoring thyroid function during trophoblastic disease treatment.
  • High hCG levels can impact thyroid hormone levels, necessitating careful interpretation of results.
  • Further investigation into thyroid homeostasis mechanisms in trophoblastic disease is warranted.