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Glycan-Based Cell Targeting To Modulate Immune Responses.

Timo Johannssen1, Bernd Lepenies2

  • 1Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany; Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Arnimallee 22, 14195 Berlin, Germany; University of Veterinary Medicine Hannover, Immunology Unit & Research Center for Emerging Infections and Zoonoses (RIZ), Bünteweg 17, 30559 Hannover, Germany.

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Summary
This summary is machine-generated.

Glycoengineering creates defined glycoproteins for targeted immune responses. Displaying glycans on nanoparticles effectively targets myeloid C-type lectin receptors (CLRs) for immune modulation.

Keywords:
C-type lectin receptorscarbohydratesdendritic cellsglycoengineeringimmune modulationinnate immunity

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Area of Science:

  • Biochemistry and immunology
  • Glycobiology
  • Protein engineering

Background:

  • Glycosylation is a crucial post-translational modification affecting protein function, stability, and immunogenicity in eukaryotes.
  • Defined and homogenous glycoproteins are accessible through glycoengineering using various expression systems.
  • Glycan structures can mediate cell-specific targeting and immune modulation via host lectin receptors.

Purpose of the Study:

  • To review novel strategies for accessing defined glycan structures.
  • To highlight approaches for targeting myeloid C-type lectin receptors (CLRs) for immune modulation.

Main Methods:

  • Exploration of bacterial N-glycosylation systems, yeasts, insect cells, and mammalian cells for glycoengineering.
  • Investigation of multivalent glycan display on nanoparticles, liposomes, and dendrimers.
  • Analysis of CLR targeting strategies for immune modulation.

Main Results:

  • Glycoengineering enables production of homogeneous glycoproteins with specific glycan structures.
  • Multivalent glycan display on various platforms successfully targets CLRs.
  • Targeting CLRs offers a strategy for shaping immune responses.

Conclusions:

  • Defined glycan structures are key for precise control over protein function and immune interactions.
  • Targeting myeloid C-type lectin receptors via engineered glycans presents a promising avenue for immune modulation therapies.