Comparable Neutrophil Responses for Arm and Intensity-matched Leg Exercise
Christof A Leicht1, Victoria L Goosey-Tolfrey, Nicolette C Bishop
1The Peter Harrison Centre for Disability Sport, School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, UNITED KINGDOM.
Medicine and Science in Sports and Exercise
|March 10, 2017
Summary
Arm exercise and leg exercise elicit similar neutrophil responses when performed at the same relative intensity. This suggests individuals performing arm exercise may achieve comparable exercise-induced neutrophil changes to those doing lower body exercise.
Area of Science:
- Exercise physiology
- Immunology
Background:
- Arm exercise is typically performed at lower absolute intensities than lower body exercise.
- The impact of exercise modality on intensity-dependent neutrophil responses is not fully understood.
- Investigating relative intensity is crucial for populations restricted to arm exercise.
Purpose of the Study:
- To compare neutrophil responses between arm and leg exercise at matched relative intensities.
- To determine the influence of exercise modality and relative intensity on neutrophil changes.
- To explore the role of CXCR2 in exercise-induced neutrophilia.
Main Methods:
- Twelve moderately trained men completed three 45-min constant load exercise trials.
- Trials included arm cranking and two cycling conditions (moderate and easy) at 60% of peak oxygen uptake (V˙O2peak) for arm (V˙O2peak arms) and leg (V˙O2peak legs) exercise.
- Neutrophil counts, heart rate (HR), and epinephrine levels were measured.
Main Results:
- Neutrophil counts increased in all exercise trials, but were significantly lower during easy cycling compared to arm exercise.
- Exercising heart rate and epinephrine levels were lower during easy cycling, mirroring the blunted neutrophil response.
- Neutrophil CXCR2 expression decreased during recovery across all trials.
Conclusions:
- Arm and leg exercise induce similar neutrophil responses when matched for relative intensity.
- Populations restricted to arm exercise may achieve comparable neutrophil responses to lower body exercise.
- Higher sympathetic activation and cardiac output in arm and relative intensity-matched leg exercise may explain these findings.
- Downregulation of CXCR2 may play a role in exercise-induced neutrophilia.
Related Concept Videos
01:20Exercise and Cardiovascular Response
4.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.8K
01:27Exercise and Muscle Performance
2.9K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.9K