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Feasible Relation between Glutathione Peroxidase and Febrile Seizure

Abolfazl Mahyar1, Parviz Ayazi1, Reza Dalirani2

  • 1Department of Pediatrics, Qazvin Children hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

Iranian Journal of Child Neurology
|March 10, 2017
PubMed

Insights

This study found no significant link between serum glutathione peroxidase levels and simple febrile seizures in children. Glutathione peroxidase, an antioxidant, does not appear to be involved in the development of febrile seizures.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Neurology

Background:

  • Febrile seizures are common in children.
  • Glutathione peroxidase is a key antioxidant enzyme.
  • Its role in febrile seizures is not well understood.

Purpose of the Study:

  • To investigate the relationship between serum glutathione peroxidase levels and simple febrile seizures in children.
  • To determine if glutathione peroxidase plays a role in the pathogenesis of febrile seizures.

Main Methods:

  • A case-control study was conducted with 43 children experiencing simple febrile seizures (case group) and 43 febrile children without seizures (control group).
  • Serum glutathione peroxidase levels were measured using the ELISA method.
  • Data were collected from Qazvin Children Hospital, Iran, between 2012-2013.

Main Results:

  • No statistically significant difference was found in serum glutathione peroxidase levels between the case group (166 U/ml) and the control group (141 U/ml).
  • Demographic analysis showed no significant difference in gender distribution between the groups (P=0.827).

Conclusions:

  • There is no significant relationship between serum glutathione peroxidase levels and simple febrile seizures.
  • Glutathione peroxidase does not appear to be implicated in the pathophysiology of simple febrile seizures, despite its role in the antioxidant system.
Abstract

Keywords:
Febrile SeizureGlutathione Peroxidase

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