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Development of electrosprayed artesunate-loaded core-shell nanoparticles.

Hoang Nhan Ho1,2, Ivo Laidmäe3, Karin Kogermann3

  • 1a National Institute of Pharmaceutical Technology, Hanoi University of Pharmacy , Ha Noi , Vietnam.

Drug Development and Industrial Pharmacy
|March 10, 2017
PubMed
Summary
This summary is machine-generated.

Coaxial electrospraying created core-shell nanoparticles for the anticancer drug artesunate (ART). These novel drug delivery systems show potential for improved cancer therapy by enhancing ART

Keywords:
Artesunatechitosancoaxial electrosprayingcore–shell nanoparticlespoly(lactic-co-glycolic) acid

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmacology

Background:

  • Artesunate (ART) exhibits anti-proliferative properties but faces challenges due to instability and poor solubility.
  • Developing effective drug delivery systems is crucial for enhancing ART's anti-cancer applications.

Purpose of the Study:

  • To develop nanoscale core-shell nanostructures for artesunate (ART) using coaxial electrospraying.
  • To investigate ART-loaded nanoparticles as a potential anti-cancer drug delivery system.

Main Methods:

  • Fabrication of core-shell nanoparticles (NPs) via coaxial electrospraying.
  • Characterization of NPs using X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM).
  • In vitro drug release studies using a dialysis method.

Main Results:

  • ART/poly(lactic-co-glycolic) acid (PLGA) chitosan (CS) NPs achieved a mean particle size of 303 ± 93 nm with high entrapment efficiency (80.5%).
  • In vitro release demonstrated an initial rapid release followed by sustained release, fitting the Korsmeyer-Peppas model.

Conclusions:

  • Core-shell NPs composed of PLGA and CS show promise as effective carriers for artesunate (ART).
  • This nanodelivery system has potential for improving anti-cancer drug therapy with ART.