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Targeting indolent non-Hodgkin lymphoma
Lori A Leslie1, Alan P Skarbnik1, Coleen Bejot1
1a Lymphoma Division , John Theurer Cancer Center , Hackensack , NJ , USA.
Expert Review of Hematology
|March 10, 2017
Summary
Novel targeted therapies are emerging for indolent non-Hodgkin lymphoma (iNHL), offering new treatment avenues. This review summarizes agents targeting B-cell malignancies, including antibody-drug conjugates and B-cell receptor pathway inhibitors.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Recent advances in understanding B-cell malignancies fuel the development of innovative therapies.
- Indolent non-Hodgkin lymphoma (iNHL) encompasses subtypes like follicular lymphoma and Waldenström macroglobulinemia.
- Targeting molecular pathogenesis is key to developing effective iNHL treatments.
Purpose of the Study:
- To provide a comprehensive summary of novel therapeutic agents for iNHL.
- To review targeted therapies impacting surface antigens, signaling pathways, and the tumor microenvironment.
- To consolidate information on emerging treatments for various iNHL subtypes.
Main Methods:
- Literature search for preclinical data and clinical trials.
- Focus on targeted therapies in iNHL.
- Review of specific drug classes including monoclonal antibodies, B-cell receptor pathway inhibitors, and CAR T-cells.
Main Results:
- Identified numerous novel agents with demonstrated activity in iNHL.
- Cataloged therapies targeting surface antigens, signaling pathways, and the tumor microenvironment.
- Reviewed a broad spectrum of therapeutic classes, including immunomodulatory agents and epigenetic modifiers.
Conclusions:
- Novel agents show promise for treating indolent non-Hodgkin lymphoma.
- Strategic development and combination therapies are crucial for optimizing treatment outcomes.
- Future directions include exploring curative options with immunotherapy and cellular therapy, alongside economic impact assessments.
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