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Related Experiment Videos

MPDP+ causes a non-reversible decrease in neostriatal synaptic transmission in mouse brain slice.

J A Wilson1, J S Wilson, F F Weight

  • 1Laboratory of Preclinical Studies, National Institute on Alcohol, Abuse and Alcoholism, Rockville, MD 20852.

Brain Research
|November 10, 1987
PubMed
Summary

MPTP causes Parkinson's-like symptoms. Researchers found that MPDP+, an MPTP metabolite, causes non-reversible synaptic transmission decrease, suggesting it is the toxic agent.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Pharmacology

Background:

  • MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces Parkinsonism.
  • Monoamine oxidase B (MAO-B) is necessary for MPTP's toxicity, suggesting a metabolite is responsible.

Purpose of the Study:

  • To identify the specific MPTP metabolite responsible for its neurotoxic effects.
  • To compare the neurotoxic potential of MPDP+ and MPP+.

Main Methods:

  • Utilized mouse brain slice preparations.
  • Assessed the effect of MPTP metabolites on synaptic transmission.

Main Results:

  • MPTP and its first oxidation product, MPDP+, caused a non-reversible decrease in synaptic transmission.
  • MPP+, the second oxidation product, did not cause a similar effect.

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Conclusions:

  • MPDP+ is a more likely candidate than MPP+ for the neurotoxic substance causing MPTP-induced Parkinsonism.
  • This finding clarifies the mechanism of MPTP neurotoxicity.