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Updated: Mar 6, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
A new hexahydrobenzopyran derivative from the gorgonian-derived Fungus Eutypella sp
Hai-Xia Liao1,2, Da-Wei Sun1,2, Cai-Juan Zheng3
1a Key Laboratory of Marine Drugs , The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao , People's Republic of China.
Abstract:
A new hexahydrobenzopyran derivative cytosporin L (1), and another eight known compounds were isolated from the gorgonian-derived fungus Eutypella sp. collected from the South China Sea. The structure of 1 was elucidated by comprehensive spectroscopic data. The absolute configuration of 1 was determined by a chemical reaction and the modified Mosher's method. The isolated secondary metabolites were evaluated for their antibacterial activities. Compound 1 showed antibacterial activity towards Micrococcus lysodeikticus and Enterobacter aerogenes with the same MIC values of 3.12 μM. Compounds 1-3 were evaluated for antiviral activities. Compounds 1 and 2 obviously inhibited the respiratory syncytial virus (RSV) with the IC50 values of 72.01 and 30.25 μM, respectively.
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