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Symbiosis

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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry
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Malaria Parasite Invasion: Achieving Superb Resolution.

Jake Baum1, Dave Richard2, David T Riglar3

  • 1Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.

Cell Host & Microbe
|March 11, 2017
PubMed
Summary
This summary is machine-generated.

Recent advances allow visualizing malaria parasite Plasmodium falciparum infecting red blood cells at the sub-cellular level. This review covers the methods and discoveries illuminating this critical step in malaria pathogenesis.

Keywords:
erythrocyteinvasionmalariamerozoiteplasmodiumsuper resolution microscopytight junction

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Area of Science:

  • Malariology
  • Cellular Biology
  • Parasitology

Background:

  • Malaria remains a significant global health challenge, caused by the Plasmodium parasite.
  • Understanding Plasmodium falciparum's invasion of red blood cells is crucial for developing effective interventions.

Purpose of the Study:

  • To review the evolution of methodologies enabling sub-cellular resolution of red blood cell invasion by Plasmodium falciparum.
  • To highlight key advancements in understanding this critical host-pathogen interaction.

Main Methods:

  • Review of microscopy techniques, including super-resolution microscopy.
  • Analysis of molecular and genetic tools used to study parasite invasion.
  • Integration of imaging and functional assays.

Main Results:

  • Sub-cellular resolution of Plasmodium falciparum invasion is a recent achievement.
  • New methodologies have revealed intricate details of the invasion process.
  • Understanding parasite entry mechanisms has significantly advanced.

Conclusions:

  • Technological progress has revolutionized the study of malaria parasite invasion.
  • Continued research into Plasmodium falciparum red cell invasion is vital for malaria control.
  • Sub-cellular insights offer new targets for anti-malarial drug development.