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Related Experiment Video

Updated: Mar 6, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

What to Expect When You're Expecting Zika.

Helen M Lazear¹

¹Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

Cell Host & Microbe

|March 11, 2017

Summary

The 2015 Zika virus (ZIKV) emergence spurred research into its pathogenesis. This review highlights the development of a crucial ZIKV mouse model, aiding scientific understanding.

Area of Science:

Virology
Infectious Diseases
Pathogenesis Research

Background:

The 2015 emergence of Zika virus (ZIKV) in the Americas increased global focus on the virus.
Previous understanding of ZIKV pathogenesis was limited due to a lack of effective experimental models.

Purpose of the Study:

To provide a historical perspective on the development of a ZIKV mouse model.
To underscore the importance of experimental models in understanding viral diseases.

Main Methods:

Retrospective review of research events leading to ZIKV mouse model creation.
Discussion of the impact of the model on ZIKV research.

Main Results:

The development of a ZIKV mouse model significantly accelerated research into its pathogenesis.

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Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

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Last Updated: Mar 6, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

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This model has been instrumental in understanding ZIKV's effects.

Conclusions:

Experimental models, like the ZIKV mouse model, are vital for rapid scientific advancement.
Continued development of robust model systems is crucial for combating emerging infectious diseases.