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Related Experiment Video

Updated: Mar 6, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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Can Functional Testing for Ischemia and Viability Guide Revascularization?

Lisa M Mielniczuk1, Gabor G Toth2, Joe X Xie3

  • 1Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada.

JACC. Cardiovascular Imaging
|March 11, 2017
PubMed
Summary

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Validation of contemporary methods to assess vessel specific myocardial mass.

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Impact of Bifurcation Lesions on Outcomes After FFR-Guided PCI or CABG.

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Gender-Based Specificities of Fractional Flow Reserve Measurement.

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Cardiac imaging guides treatment for heart disease by assessing severity and risk. Ongoing trials will refine its role in improving patient outcomes through better management decisions.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Clinical Trials

Background:

  • Cardiac imaging is crucial for diagnosing and managing heart disease.
  • Optimal patient management relies on assessing symptom burden, risk, and disease severity.
  • Flow measurements and ischemia/viability imaging inform revascularization and intervention decisions.

Purpose of the Study:

  • To review the current role of cardiac imaging in managing ischemic heart disease and heart failure.
  • To highlight the impact of imaging on clinical decision-making and patient outcomes.
  • To discuss evidence from ongoing randomized trials that will shape future practice.

Main Methods:

  • Review of recent clinical trials and their findings on cardiac imaging.
  • Analysis of the strengths and limitations of various imaging modalities.
Keywords:
PETcoronary revascularizationfractional flow reserveheart failureischemic heart disease

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  • Discussion of the indirect effect of imaging on patient outcomes through management decisions.

    • Main Results:

    • Flow measurements effectively guide revascularization decisions.
    • Ischemia and viability imaging serve as important risk markers for interventions.
    • Evaluating imaging's impact on outcomes is challenging due to its influence on management choices.

    Conclusions:

    • Cardiac imaging plays a vital role in guiding therapeutic decisions for patients with ischemic heart disease.
    • Ongoing randomized trials like FAME 3, ISCHEMIA, and IMAGE-HF will provide high-level evidence.
    • Future practice changes informed by these studies are expected to improve patient outcomes.