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YAP and WWTR1: New targets for skin cancer treatment

Thomas Andl1, Linli Zhou2, Kun Yang2

  • 1Burnett School of Biological Sciences, University of Central Florida, Orlando, FL 32816, USA.

Cancer Letters
|March 11, 2017
PubMed

Insights

The Hippo pathway

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • The Hippo signaling pathway, a tumor suppressor, regulates cell growth and proliferation.
  • Dysregulation of the Hippo pathway, particularly YAP/WWTR1, is implicated in various human cancers.
  • YAP/WWTR1 integrate signals to control cell behavior and interactions.

Purpose of the Study:

  • To review the latest findings on YAP/WWTR1 in skin physiology and pathology.
  • To discuss the role of YAP/WWTR1 in skin tumorigenesis.
  • To explore therapeutic interventions targeting YAP/WWTR1 for skin cancer treatment.

Main Methods:

  • Literature review of recent studies on the Hippo signaling pathway.
  • Analysis of YAP/WWTR1 function in skin homeostasis and disease.
  • Evaluation of emerging therapeutic strategies targeting YAP/WWTR1.

Main Results:

  • YAP/WWTR1 play a dual role in cancer, acting as tumor suppressors but also promoting uncontrolled growth when dysregulated.
  • YAP/WWTR1 integrate diverse signals to modulate cell social behavior.
  • Recent therapeutic strategies targeting YAP/WWTR1 show promise for cancer treatment.

Conclusions:

  • YAP/WWTR1 are critical regulators of cell behavior with significant implications in skin cancer.
  • Targeting YAP/WWTR1 represents a promising therapeutic avenue for skin cancer.
  • Further research is needed to fully elucidate YAP/WWTR1 roles and optimize therapeutic interventions.
Keywords:
CancerHippo signalingSkinTherapeuticsWWTR1YAP

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