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PBCA-based polymeric microbubbles for molecular imaging and drug delivery.

Patrick Koczera¹, Lia Appold², Yang Shi²

¹Department of Experimental Molecular Imaging (ExMI), Helmholtz Institute for Biomedical Engineering, University Hospital RWTH, Pauwelsstr. 30, 52074 Aachen, Germany; Department of Intensive Care, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

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|March 11, 2017

Summary

Poly(n-butyl cyanoacrylate) microbubbles (MB) enable advanced ultrasound (US) imaging and drug delivery. These targeted MBs visualize disease and enhance drug penetration, improving diagnosis and therapy.

Keywords:

Microbubbles Nanomedicine Sonoporation Tumor targeting Ultrasound

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Area of Science:

Biomedical Engineering
Nanotechnology
Medical Imaging

Background:

Microbubbles (MB) are established ultrasound (US) contrast agents.
Targeted and drug-loaded MBs offer potential for advanced biomedical applications.
Poly(n-butyl cyanoacrylate) (PBCA) MBs are explored for molecular imaging and drug delivery.

Purpose of the Study:

To describe targeted and drug-loaded PBCA MBs.
To demonstrate their utility in molecular US imaging and US-mediated drug delivery.
To highlight their potential in improving disease diagnosis and therapy.

Main Methods:

Surface modification of PBCA MBs with peptides/antibodies for molecular imaging (targeting E-selectin, VCAM-1).
Utilizing stable and inertial cavitation of PBCA MBs for sonoporation and vessel permeabilization.
Investigating direct (US-induced release) and indirect (enhanced extravasation) drug delivery mechanisms.

Main Results:

PBCA MBs successfully visualized angiogenic tumor vessels and inflamed atherosclerotic endothelium.
Sonoporation and vessel permeabilization were achieved in tumors and the brain.
Both direct and indirect drug delivery strategies were demonstrated as effective.

Conclusions:

Targeted and drug-loaded PBCA MBs are suitable for molecular US imaging and US-mediated drug delivery.
Combining MBs with US shows broad applicability for improved disease diagnosis and therapy.
These findings align with recent advancements in patient-applicable MB technology.