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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

33.1K
Overview
33.1K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

92
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Hypersensitivities01:30

Hypersensitivities

8.0K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.0K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

70
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
70
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

80
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
80
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.5K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K

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Related Experiment Video

Updated: Mar 6, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency

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Pediatric anaphylaxis and hyper IgE syndrome.

Amrita Dosanjh1

  • 1Department of Pediatrics, Rady Childrens Hospital, San Diego, CA, USA.

Journal of Asthma and Allergy
|March 11, 2017
PubMed
Summary

Autosomal-dominant Hyper IgE syndrome (AD HIES), or Job syndrome, is linked to severe infections and extremely high IgE levels. This study investigates the connection between AD HIES and anaphylaxis, a severe allergic reaction.

Area of Science:

  • Immunology
  • Genetics
  • Allergy

Background:

  • Autosomal-dominant Hyper IgE syndrome (AD HIES), also known as Job syndrome, is a primary immunodeficiency.
  • Characterized by extremely elevated serum IgE levels, AD HIES leads to recurrent skin and lung infections.
  • The molecular basis and clinical spectrum of Job syndrome are known, but its association with severe allergic reactions requires further study.

Purpose of the Study:

  • To analyze the association between Autosomal-dominant Hyper IgE syndrome (AD HIES) and anaphylaxis.
  • To investigate the link between Job syndrome and severe allergic reactions.

Main Methods:

  • Database analysis of patients with Autosomal-dominant Hyper IgE syndrome (AD HIES) or Job syndrome.
  • Review of clinical data focusing on allergic reactions and anaphylaxis.
Keywords:
allergyanaphylaxishyper IgE syndromepediatrics

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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Main Results:

  • Patients with AD HIES exhibit extremely elevated IgE levels.
  • The study focuses on the association between AD HIES, Job syndrome, and anaphylaxis.
  • The relationship between Job syndrome and severe allergic reactions is an area of ongoing research.

Conclusions:

  • Further investigation is needed to fully understand the association between Autosomal-dominant Hyper IgE syndrome (AD HIES) and anaphylaxis.
  • Clarifying the link between Job syndrome and severe allergic reactions is crucial for patient management.