Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

9.2K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.2K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

514
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
514
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.3K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.3K
Radiation Pressure: Problem Solving01:09

Radiation Pressure: Problem Solving

901
The radiation pressure applied by an electromagnetic wave on a perfectly absorbing surface equals the energy density of the wave. The wave's momentum also gets transferred to the surface when an electromagnetic wave is entirely absorbed by it. The rate at which momentum is transmitted to an absorbing surface perpendicular to the propagation direction equals the force on the surface.
The average value of the rate of momentum transfer divided by the absorbing area represents the average force...
901
Region of Convergence of Laplace Tarnsform01:20

Region of Convergence of Laplace Tarnsform

1.3K
The Region of Convergence (ROC) is a fundamental concept in signal processing and system analysis, particularly associated with the Laplace transform. The ROC represents an area in the complex plane where the Laplace transform of a given signal converges, determining the transform's applicability and utility.
Consider a decaying exponential signal that begins at a specific time. When deriving its Laplace transform, the time-domain variable is replaced with a complex variable. This...
1.3K
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

13.6K
Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
13.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of disitamab vedotin (RC48) combined with camrelizumab and S-1 for neoadjuvant therapy of locally advanced gastric cancer with HER2-overexpressing: Preliminary results of a prospective, single-arm, phase II study.

Clinical and translational medicine·2026
Same author

Application of a Nursing Quality Improvement Checklist in the Emergency Treatment of Trauma Patients.

Risk management and healthcare policy·2026
Same author

Integrated Transcriptomic and Metabolomic Analysis Reveals the Antibacterial Mechanisms of the Novel Peptide FxCy2 against <i>Helicobacter pylori</i>.

Journal of agricultural and food chemistry·2026
Same author

Nuclear translocation of SLC25A10 isoform 3 promotes chemoresistance in HCC cells via CEBPB/BCL2A1 signaling.

Cell death & disease·2026
Same author

Bioinspired Dual-Scale Crack Manipulation Enabling 325%-Stretchable Metal Film Conductors for AI-Empowered Electronic Skins.

Nano-micro letters·2026
Same author

Comparative value of novel inflammatory indices in predicting incident carotid atherosclerosis: SIRI outperforms other markers in a general population.

Frontiers in cardiovascular medicine·2026

Related Experiment Video

Updated: Mar 6, 2026

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
16:44

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Published on: June 2, 2009

10.8K

Mixed Total Variation and L1 Regularization Method for Optical Tomography Based on Radiative Transfer Equation.

Jinping Tang1, Bo Han1, Weimin Han2

  • 1Department of Mathematics, Harbin Institute of Technology, Harbin, Heilongjiang Province, China.

Computational and Mathematical Methods in Medicine
|March 11, 2017
PubMed
Summary

This study introduces a novel optical tomography method for reconstructing tissue absorption coefficients using combined total variation (TV) and L1 regularization. The advanced technique demonstrates accurate and efficient imaging reconstruction for molecular imaging applications.

More Related Videos

Near Infrared Optical Projection Tomography for Assessments of &#946;-cell Mass Distribution in Diabetes Research
15:18

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

Published on: January 12, 2013

17.0K
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

12.9K

Related Experiment Videos

Last Updated: Mar 6, 2026

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
16:44

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Published on: June 2, 2009

10.8K
Near Infrared Optical Projection Tomography for Assessments of &#946;-cell Mass Distribution in Diabetes Research
15:18

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

Published on: January 12, 2013

17.0K
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

12.9K

Area of Science:

  • Biomedical optics
  • Molecular imaging
  • Medical physics

Background:

  • Optical tomography is an emerging imaging modality for reconstructing human tissue optical properties.
  • Accurate reconstruction of optical properties, like absorption coefficient, is crucial for molecular imaging.
  • Ill-posed inverse problems in optical tomography often require regularization techniques.

Purpose of the Study:

  • To develop and validate a novel optical tomography method for reconstructing the absorption coefficient based on the radiative transfer equation (RTE).
  • To enhance reconstruction accuracy for piecewise constant and sparse coefficient distributions by combining Total Variation (TV) and L1 regularization norms.

Main Methods:

  • Discretization of the forward problem using the discontinuous Galerkin method (spatial) and finite element method (angular).
  • Solving the minimization problem with a Jacobian-based Levenberg-Marquardt type method incorporating split Bregman algorithms for L1 regularization.
  • Utilizing the adjoint method for efficient computation of the Jacobian matrix.

Main Results:

  • The proposed method effectively reconstructs absorption coefficients from optical tomography data.
  • Simulation results demonstrate the validity and efficiency of the combined TV and L1 regularization approach.
  • The adjoint method significantly improves computational efficiency compared to other reconstruction methods.

Conclusions:

  • The combined TV and L1 regularization offers superior reconstruction of piecewise constant and sparse optical properties in tissues.
  • The developed optical tomography method is efficient and accurate for molecular imaging applications.
  • This approach advances the field of optical tomography for biomedical applications.