Related Experiment Video
Updated: Mar 6, 2026
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
Outcome of young patients with rectal adenocarcinoma
Leonardo Saúl Lino-Silva1, Rosa A Salcedo-Hernández2, Erika B Ruiz-García3
1Gastrointestinal Pathology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.
Background:
There is an increase in the incidence of rectal carcinoma (RC) in young patients.
Methods:
We analyzed 175 patients with sporadic RC which were divided in two groups according their age: 24 patients ≤40 years and 151 patients >40 years and the two groups were compared in order to determine if the outcomes (especially overall 5-year survival) were different.
Results:
Overall 5-year survival was similar between groups (67.1% for patients over 40 years and 70.4% for those under 40 years, P=0.803). The only differences found were in some clinicopathologic features: patients <40 years showed more dissected lymph nodes (LNs) (21 vs. 15, P=0.035) and more LN metastasis (54.2% vs. 39.1%, P=0.048). In multivariate analysis factors associated with worse survival were incomplete resection and no use of neoadjuvant therapy. Age did not demonstrate prognostic value (P=0.077).
Conclusions:
RC in people ≤40 years demonstrated greater number of LN harvested and LN metastases but oncologic outcomes, especially 5-year overall survival, were similar between groups.
