The concept of 'borderline resectable' pancreatic cancer: limited foundations and limited future?
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Updated: Mar 6, 2026
Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction
Published on: January 3, 2020
John A Windsor1, Savio George Barreto2
1HBP/Upper GI Unit, Department of General Surgery, Auckland City Hospital, Auckland, New Zealand;; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is traditionally treated by a surgery-first approach. The development and adoption of the concept of borderline resectable PDAC, which extends the role of surgery, is based on the proposition that neoadjuvant therapy (NAT) will increase the resection rate, margin negative rate and overall survival. There are a number of issues with this concept and a critical review of these suggests that it is based on limited foundations and likely has a limited future.
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