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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
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Resolution of Primary Lymphedema: A Case Report
Jeremy A Goss1, Reid A Maclellan1, Usha E A Beijnen1
1Department of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Plastic and Reconstructive Surgery. Global Open
|March 11, 2017
Summary
Primary lymphedema, a progressive lower extremity disease, typically worsens over time. This case study documents the unexpected resolution of primary lymphedema, offering new insights into its underlying causes.
Area of Science:
- Medical research
- Pathophysiology
- Clinical case study
Background:
- Primary lymphedema is a rare, incurable condition causing progressive lower extremity enlargement.
- Subcutaneous fibroadipose deposition drives limb enlargement in lymphedema.
- Current understanding of primary lymphedema pathophysiology is incomplete.

