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Related Concept Videos

Micelles01:30

Micelles

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Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
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Related Experiment Video

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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
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Lyotropic liquid crystal engineering moving beyond binary compositional space - ordered nanostructured amphiphile

Leonie van 't Hag1, Sally L Gras, Charlotte E Conn

  • 1Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

Chemical Society Reviews
|March 11, 2017
PubMed
Summary

Engineered amphiphilic self-assembly materials with tunable 3D nanostructures are vital for biomedical uses. This review summarizes additives that alter lipidic cubic phases, providing design rules for advanced materials.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Physical Chemistry

Background:

  • Ordered amphiphile self-assembly materials with tunable 3D nanostructures are crucial for applications like protein crystallization, drug delivery, biosensors, and biofuel cells.
  • Tuning these properties in binary amphiphile-solvent systems is limited, necessitating exploration beyond binary compositions.
  • Engineering material properties requires moving beyond simple binary systems to achieve desired functionalities.

Purpose of the Study:

  • To critically review phase transitions upon encapsulating over 130 additives into bicontinuous lipidic cubic phases.
  • To interpret these transitions using geometric, interfacial curvature, electrostatic, and miscibility principles.
  • To establish engineering design rules for lyotropic liquid crystals and create a library of self-assembly materials.

Main Methods:

  • Summarization of phase transitions from existing literature for over 130 additives.
  • Interpretation of data using geometric considerations and interfacial curvature.
  • Analysis of electrostatic interactions, partition coefficients, and alkyl chain miscibility.

Main Results:

  • Detailed summary of phase transitions observed upon additive encapsulation in lipidic cubic phases.
  • Identification of key factors governing phase behavior, including geometry, curvature, and intermolecular forces.
  • Development of engineering design rules for formulating self-assembly materials.

Conclusions:

  • Additive encapsulation offers a powerful strategy to tune 3D nanostructure and properties of amphiphilic self-assembly materials.
  • Established design rules facilitate the rational engineering of these materials for specific biomedical applications.
  • A comprehensive library of tunable self-assembly materials is provided for advancing biomedical technologies.