Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

58
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
58
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

65
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
65
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

131
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
131
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

74
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
74
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

58
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
58
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

58
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
58

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergent molecular mechanisms underlie differential toxicity of trivalent lanthanum and divalent cadmium in Enchytraeus crypticus.

Ecotoxicology and environmental safety·2026
Same author

NF-κB p65 modulates the promoter activity of large yellow croaker (Larimichthys crocea) interleukin-2.

Developmental and comparative immunology·2026
Same author

Unraveling the Mechanism of Perillyl Alcohol and Its Derivatives as Potent Antifungal Agents against Gray Mold.

Journal of agricultural and food chemistry·2026
Same author

GLP-1RA Liraglutide Attenuates Sepsis by Modulating Gut Microbiota and Associated Metabolites.

Nutrients·2026
Same author

Structural and mechanistic insights into caseinolytic protease inhibition for antimicrobial development against Pseudomonas plecoglossicida.

PLoS pathogens·2026
Same author

Spatiotemporally Cascade-Releasing Polyester Nanoparticles for Synergistic Photodynamic/Chemo/Gene Therapy of Colorectal Cancer.

Advanced healthcare materials·2026

Related Experiment Video

Updated: Mar 6, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

25.4K

NO-Responsive vesicles as a drug delivery system.

Zhi-Heng Li1, Zheng-Li Tan1, Ai-Xiang Ding1

  • 1Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China. luzl@bnu.edu.cn.

Chemical Communications (Cambridge, England)
|March 11, 2017
PubMed
Summary

Researchers developed a novel amphiphile that forms vesicles for drug delivery. This system is the first to be responsive to nitric oxide (NO), enabling targeted release.

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.4K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

3.9K

Related Experiment Videos

Last Updated: Mar 6, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

25.4K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.4K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

3.9K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Drug Delivery Systems

Background:

  • Amphiphiles are molecules with both hydrophobic and hydrophilic parts.
  • Vesicles are self-assembling structures that can encapsulate substances.
  • Nitric oxide (NO) plays various roles in biological processes and is a target for drug delivery modulation.

Purpose of the Study:

  • To design and synthesize a novel amphiphile capable of forming vesicles.
  • To investigate the self-assembly properties of the designed amphiphile in aqueous solution.
  • To establish the first nitric oxide (NO)-responsive drug delivery system.

Main Methods:

  • Rational design of an amphiphile incorporating a hydrophobic Hantzsch ester and a hydrophilic phosphate ester.
  • Characterization of vesicle formation in aqueous media using techniques like dynamic light scattering and transmission electron microscopy.
  • Evaluation of the NO-responsiveness of the formed vesicles.

Main Results:

  • The rationally designed amphiphile successfully formed stable vesicles in aqueous solution.
  • The vesicles demonstrated responsiveness to nitric oxide (NO).
  • This represents the first reported instance of a NO-responsive vesicle-based drug delivery system.

Conclusions:

  • A novel amphiphile was successfully synthesized and self-assembled into vesicles.
  • The developed system is the first example of a nitric oxide (NO)-responsive drug delivery platform.
  • This finding opens new avenues for targeted and stimuli-responsive therapeutic strategies.