Related Experiment Video

Updated: Mar 6, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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A growing role for the Hippo signaling pathway in the heart

Yu Zhang1, Dominic P Del Re2

  • 1Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB G-609, Newark, NJ, 07103-2714, USA.

Journal of Molecular Medicine (Berlin, Germany)
|March 11, 2017
PubMed

Insights

The Hippo signaling pathway regulates heart cell survival and proliferation. Understanding this pathway offers therapeutic targets for heart disease and failure.

Area of Science:

  • Cardiovascular Biology
  • Molecular Signaling
  • Regenerative Medicine

Background:

  • Heart disease causes significant global mortality and economic burden.
  • Loss of cardiomyocytes after myocardial infarction leads to heart failure.
  • The heart has limited regenerative capacity.

Purpose of the Study:

  • To review the role of the Hippo signaling pathway in cardiomyocyte survival and proliferation.
  • To explore the impact of Hippo signaling on the stressed adult heart.
  • To highlight therapeutic potential for heart regeneration.

Main Methods:

  • Review of existing literature on Hippo signaling in the heart.
  • Analysis of canonical and non-canonical Hippo pathway functions.
  • Focus on cardiomyocyte proliferation and survival mechanisms.

Main Results:

  • The Hippo pathway is conserved and regulates organ size.
  • This pathway is critical for heart development, homeostasis, and response to injury.
  • Hippo signaling influences cardiomyocyte proliferation and survival in the adult heart.

Conclusions:

  • The Hippo pathway is a key regulator of cardiac cell fate.
  • Targeting Hippo signaling presents a promising strategy for treating heart disease.
  • Further research into Hippo signaling could unlock cardiac regenerative therapies.

Keywords:
CardiomyocyteHeart diseaseHippo pathway

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