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Glutamine Addiction In Gliomas.

Javier Márquez1, Francisco J Alonso2, José M Matés2

  • 1Canceromics lab, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Instituto de Biomedicina de Málaga (IBIMA), Universidad de Málaga, 29071, Málaga, Spain. marquez@uma.es.

Neurochemical Research
|March 11, 2017
PubMed
Summary

Cancer cells exhibit altered metabolism, including high glutamine (Gln) consumption, a phenomenon termed "Gln addiction." This review explores Gln addiction in glioma, highlighting its role in tumor growth and potential as a therapeutic target.

Keywords:
Anticancer therapyGliomasGlutamateGlutaminasesGlutamine-addictionGlutaminolysisMetabolic reprogramming

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Area of Science:

  • Oncology
  • Cancer Metabolism
  • Biochemistry

Background:

  • Cancer cells exhibit distinct metabolic reprogramming, including the Warburg effect (increased glycolysis) and high glutamine consumption.
  • Glutamine addiction describes the critical dependence of most cancer cells on glutamine for growth and proliferation after metabolic shifts.
  • A glutamine/glutamate cycle between host tissues and tumors supports tumor growth and survival.

Purpose of the Study:

  • To provide an updated overview of glutamine addiction in glioma.
  • To discuss the mechanistic basis of deregulated tumor metabolism in cancer.
  • To explore novel therapeutic strategies targeting glutamine metabolism in brain tumors.

Main Methods:

  • Literature review of glutamine metabolism in cancer.
  • Analysis of metabolic reprogramming in cancer cells.
  • Discussion of oncogenic and tumor suppressor pathways influencing metabolism.

Main Results:

  • Glutamine addiction is a key metabolic feature in most cancer cells, including glioma.
  • Understanding glutamine metabolism provides insights into tumor growth and proliferation.
  • Deregulated tumor metabolism is linked to oncogenic pathways.

Conclusions:

  • Glutamine addiction is a significant hallmark of glioma, driving tumor progression.
  • Targeting glutamine metabolism presents a promising therapeutic avenue for brain tumors.
  • Further research into the mechanistic basis of glutamine addiction can yield novel anticancer strategies.