Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular mechanisms of coronary microembolization-induced MINOCA.

Basic research in cardiology·2026
Same author

Reply: Strengths and Limitations of the Renal Locoregional Perfusion Platform.

JACC. Basic to translational science·2026
Same author

Quality of life in women and men after coronary artery bypass surgery.

JTCVS open·2026
Same author

Small Diameter Vascular Grafts Made in Minutes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Reply: Hydrodissection for conduit harvesting: Catch the wave!

JTCVS open·2026
Same author

Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication.

Nature reviews. Cardiology·2026
Same journal

Correction: A Hidden Indicator of Cardiovascular Health: Serum Gamma-Glutamyl Transferase in Focus.

Journal of cardiovascular translational research·2026
Same journal

ChemoCardioNet: An Explainable Multimodal Transformer for Early Prediction of Chemotherapy-Induced Cardiotoxicity.

Journal of cardiovascular translational research·2026
Same journal

Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis.

Journal of cardiovascular translational research·2026
Same journal

The Immediate Impact of Infarct Size on the Systemic Inflammatory Response: IL-6 as Central Mediator Identified through Biomarker and Proteomic Profiling.

Journal of cardiovascular translational research·2026
Same journal

Extracellular Vesicles Link Cerebral Ischemia to Coronary Microvascular Dysfunction - Role for RGD Motif-Activated Endothelin Signaling.

Journal of cardiovascular translational research·2026
Same journal

Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity.

Journal of cardiovascular translational research·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
10:41

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Published on: January 23, 2021

8.6K

Translational Challenges in Cardiovascular Tissue Engineering.

Maximilian Y Emmert1,2,3, Emanuela S Fioretta1, Simon P Hoerstrup4,5

  • 1Institute for Regenerative Medicine (IREM), University of Zurich, Moussonstrasse 13, 8091, Zurich, Switzerland.

Journal of Cardiovascular Translational Research
|March 11, 2017
PubMed
Summary
This summary is machine-generated.

Tissue engineering (TE) offers regenerative cardiovascular replacements but faces significant translational challenges. Overcoming scientific, clinical, and regulatory hurdles is crucial for widespread clinical adoption of these advanced therapies.

Keywords:
Clinical translationOff-the-shelfRegenerative medicineRemodelingSelf-repair capacityTissue engineering

More Related Videos

Capillary Force Lithography for Cardiac Tissue Engineering
10:09

Capillary Force Lithography for Cardiac Tissue Engineering

Published on: June 10, 2014

13.0K
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

11.7K

Related Experiment Videos

Last Updated: Mar 6, 2026

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
10:41

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Published on: January 23, 2021

8.6K
Capillary Force Lithography for Cardiac Tissue Engineering
10:09

Capillary Force Lithography for Cardiac Tissue Engineering

Published on: June 10, 2014

13.0K
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

11.7K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Valvular heart disease and congenital heart defects are leading global causes of mortality.
  • Current artificial heart prostheses are suboptimal, lacking regenerative and growth capabilities, leading to degeneration and re-interventions.
  • Tissue engineering (TE) presents a promising approach for native-like cardiovascular replacements, especially for pediatric patients.

Purpose of the Study:

  • To review the translational challenges hindering the clinical adoption of tissue engineering (TE) cardiovascular replacements.
  • To identify scientific, clinical, logistical, technical, and regulatory barriers to TE translation.
  • To propose solutions and future directions for accelerating the clinical translation of TE technologies.

Main Methods:

  • Comprehensive literature review of tissue engineering approaches for cardiovascular applications.
  • Analysis of pre-clinical and early clinical trial data.
  • Examination of current regulatory guidelines and their impact on TE translation.

Main Results:

  • Despite promising pre-clinical data, the clinical translation of TE cardiovascular replacements remains limited.
  • Multifaceted challenges, including scientific, clinical, logistical, technical, and regulatory issues, impede broad adoption.
  • Specific focus on regulatory hurdles and their implications for TE technologies.

Conclusions:

  • Addressing the identified translational challenges is essential for realizing the full potential of TE in cardiovascular medicine.
  • Strategic solutions are needed to accelerate the clinical translation of regenerative cardiovascular replacements.
  • Navigating regulatory pathways effectively is critical for the successful implementation of TE therapies.