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Biosensing Based on Magneto-Optical Surface Plasmon Resonance.

Sorin David1, Cristina Polonschii1, Mihaela Gheorghiu1

  • 1International Centre of Biodynamics, Intrarea Portocalelor 1B, Bucharest, 060101, Romania.

Methods in Molecular Biology (Clifton, N.J.)
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PubMed
Summary

Magneto Optical Surface Plasmon Resonance (MOSPR) biosensing is improved with a novel chip structure and measurement techniques. This enhances stability and sensitivity for detecting minute analyte concentrations in saline solutions.

Keywords:
Affinity biosensorAngle-resolved surface plasmon resonanceFixed-angle surface plasmon resonanceMagnetic alloysMagneto-optic surface plasmon resonanceSurface plasmon resonance enhancement

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Magneto Optical Surface Plasmon Resonance (MOSPR) assays offer high analytical potential for biosensing.
  • Current MOSPR applications are hindered by significant chip stability issues, limiting their use in biosensing.
  • Existing MOSPR chips lack structural stability in saline solutions, restricting bioaffinity assays.

Purpose of the Study:

  • To overcome limitations in MOSPR sensing assays by introducing innovative chip structures, tailored measurements, and improved data analysis.
  • To enhance the stability and applicability of MOSPR biosensing platforms.
  • To improve the signal-to-noise ratio for detecting minute analyte concentrations.

Main Methods:

  • A novel chip structure utilizing a Co-Au alloy layer instead of homogenous metal layers was developed.
  • A custom measurement configuration was designed to acquire the SPR curve (reflectivity at multiple angles of incidence).
  • Improved data analysis methods were implemented to enhance signal processing and stability assessment.

Main Results:

  • The new Co-Au alloy chip structure exhibits improved plasmonic and magnetic properties while maintaining structural stability similar to standard Au-SPR chips.
  • The custom measurement configuration achieved a high signal-to-noise ratio, enabling the detection of minute analyte concentrations.
  • The MOSPR sensing chip demonstrated long-term assessment capability in liquid media, surpassing existing MOSPR chip limitations.
  • The study confirmed the increased sensitivity of MOSPR compared to standard SPR analyses.

Conclusions:

  • The developed MOSPR sensing chip, measurement configuration, and data analysis provide a stable and highly sensitive platform for biosensing.
  • This advancement significantly broadens the applicability of MOSPR assays in biosensing, particularly in saline environments.
  • The novel approach confirms the superior sensitivity of MOSPR over traditional SPR methods for detecting low analyte concentrations.