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Label-Free Biosensors Based on Bimodal Waveguide (BiMW) Interferometers.

Sonia Herranz1, Adrián Fernández Gavela1, Laura M Lechuga2,3

  • 1Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology, 08193, Bellaterera, Barcelona, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|March 11, 2017
PubMed
Summary

The bimodal waveguide (BiMW) sensor offers sensitive, label-free detection of biomolecular interactions. This cost-effective, portable biosensor has applications in environmental monitoring and clinical diagnostics.

Keywords:
Bimodal waveguide interferometryBiofunctionalizationBiorecognitionEvanescent field biosensorImmunoassayIntegrated optics

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Area of Science:

  • Biophotonics
  • Nanotechnology
  • Biosensing

Background:

  • The bimodal waveguide (BiMW) sensor is a novel common path interferometric transducer.
  • It utilizes evanescent field detection for label-free biomolecular interaction analysis.
  • High sensitivity makes it suitable for environmental, medical, and food safety applications.

Purpose of the Study:

  • To describe the design and fabrication of the BiMW transducer.
  • To demonstrate the biosensor capabilities of the BiMW transducer in diverse applications.
  • To highlight its potential for point-of-care (POC) settings.

Main Methods:

  • Fabrication of the BiMW transducer using standard silicon-based technology.
  • Real-time detection by monitoring light intensity pattern changes.
  • Utilizing antigen-antibody interactions for biosensing.

Main Results:

  • Demonstrated immunodetection of Irgarol 1051 biocide for environmental monitoring.
  • Showcased detection of human growth hormone for clinical diagnostics.
  • Confirmed label-free, real-time biomolecular interaction detection.

Conclusions:

  • The BiMW sensor is a cost-effective, portable, and disposable biosensor.
  • It enables sensitive, label-free detection of biomolecular interactions.
  • The BiMW sensor shows significant potential for environmental and clinical diagnostic applications.