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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Silicates in orthopedics and bone tissue engineering materials.

Xianfeng Zhou1,2, Nianli Zhang3, Steven Mankoci1

  • 1Department of Polymer Science, University of Akron, Ohio, 44325.

Journal of Biomedical Materials Research. Part A
|March 11, 2017
PubMed
Summary
This summary is machine-generated.

Silicates show promise in bone tissue engineering by potentially enhancing bone formation and binding. This review explores the cellular mechanisms behind silica

Keywords:
bioactive materialsmechanismosteoblastosteoclastsilicate (silicasilicon)

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedics

Background:

  • Silicate-based glasses are successful bioactive materials.
  • Silicates are investigated for promoting bone formation and binding.
  • Silicate-substituted hydroxyapatite (HAP) and minerals are explored for bone and dental applications.

Purpose of the Study:

  • Review the roles of silicate in bone tissue engineering.
  • Highlight breakthroughs in understanding the cellular mechanisms of silica's osteoinductivity.
  • Inspire the design of advanced cell- and gene-affecting biomaterials.

Main Methods:

  • Literature review of studies on silicate biomaterials.
  • Analysis of cellular and molecular mechanisms of osteoinductivity.
  • Discussion of current research and future directions.

Main Results:

  • Silicates are implicated in promoting bone formation and HAP layer formation.
  • Silicate's role in osteoinductivity is supported by emerging cellular evidence.
  • Mechanisms remain incompletely understood and debated.

Conclusions:

  • Silicate biomaterials hold significant potential for bone tissue engineering.
  • Further research into cellular mechanisms is crucial for optimizing biomaterial design.
  • This review provides a foundation for developing next-generation biomaterials.