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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.5K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

Seizures: Classification

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.9K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
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Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.1K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.1K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
873
Antiepileptic Drugs: Calcium Channel Blockers01:17

Antiepileptic Drugs: Calcium Channel Blockers

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Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
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Cognitive phenotypes in adults with temporal lobe epilepsy from South Africa - A contribution to the international classification of cognitive disorders in epilepsy (IC-CoDE).

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Diagnostic Challenges in the Neuropsychology of Epilepsy: Report of the ILAE Neuropsychology Task Force Diagnostic Methods Commission: 2021-2025.

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A user's guide for the International Classification of Cognitive Disorders in Epilepsy.

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Related Experiment Video

Updated: Mar 6, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

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Comorbidities of epilepsy.

H V Srinivas1, Urvashi Shah2

  • 1Department of Neurology, Agadi Hospital and Sagar Hospital, Bengaluru, Karnataka, India.

Neurology India
|March 11, 2017
PubMed
Summary

Epilepsy comorbidities, including neurological and neuropsychiatric disorders, significantly impact quality of life and are more prevalent than in the general population. Early screening and intervention are crucial for optimal epilepsy management.

Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Epilepsy management primarily focuses on seizure control, often overlooking comorbid conditions.
  • Neurological, neuropsychiatric, and neurobehavioral disorders are common comorbidities in epilepsy, impacting patient quality of life.
  • These comorbidities share underlying pathogenesis with epilepsy and have a bidirectional relationship.

Purpose of the Study:

  • To review the spectrum of comorbidities associated with epilepsy.
  • To explore the therapeutic management of these comorbidities.
  • To highlight the need for early screening and intervention in epilepsy.

Main Methods:

  • Systematic literature search of PubMed (Jan 2006 - Aug 2016) using "comorbidities" and "epilepsy."
  • Inclusion of articles relevant to India and original research papers.

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Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
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  • Focus on neuropsychiatric, neurobehavioral, and neurological comorbidities.

    • Main Results:

    • Comorbidities in epilepsy are common, poorly understood, and often unaddressed.
    • Prevalence of comorbidities is significantly higher in epilepsy patients compared to the general population.
    • Comorbidities substantially increase the burden of epilepsy.

    Conclusions:

    • There is a wide spectrum of comorbidities impacting epilepsy management.
    • Optimal epilepsy management requires acknowledging, screening for, and intervening in comorbidities early.
    • Addressing comorbidities is essential for improving the quality of life for individuals with epilepsy.