Related Experiment Video

Updated: Mar 6, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.9K

High sensitive TROponin levels In Patients with Chest pain and kidney disease: A multicenter registry - The TROPIC

Flavia Ballocca1, Fabrizio D'Ascenzo, Claudio Moretti

  • 1Departement of Cardiology, Division of Internal Medicine, Città Della Salute e della Scienza. flaviabl@hotmail.it.

Cardiology Journal
|March 11, 2017
PubMed

Insights

High-sensitive troponin assays (hs-cTn) can help identify coronary artery disease (CAD) in patients with chronic kidney disease (CKD). Peak troponin levels, particularly hs-cTnI, predict 30-day mortality in this high-risk population.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • The diagnostic accuracy of high-sensitive troponin (hs-cTn) for coronary artery disease (CAD) in patients with renal insufficiency remains unclear.
  • Chronic kidney disease (CKD) complicates the interpretation of cardiac biomarkers.
  • Evaluating the prognostic value of hs-cTn T and I in CKD patients is crucial.

Purpose of the Study:

  • To assess the prognostic role of hs-cTn T and I in patients with CKD and chest pain.
  • To determine the predictive value of hs-cTn for the presence of CAD in this population.
  • To compare the performance of hs-cTnT and hs-cTnI assays.

Main Methods:

  • Consecutive patients with chest pain and renal insufficiency (eGFR < 60 mL/min/1.73 m2) were enrolled.
  • Baseline and interval hs-cTnT and hs-cTnI levels were measured.
  • The predictive value for CAD and 30-day mortality was analyzed using area under the curve (AUC).

Main Results:

  • No significant difference in clinical characteristics or outcomes between hs-cTnT and hs-cTnI assays.
  • Baseline hs-cTn values did not effectively differentiate between patients with or without CAD (low AUC).
  • Interval and peak hs-cTnI levels were significantly higher in patients with CAD and showed higher accuracy (AUC) compared to hs-cTnT.
  • Peak troponin levels (both T and I) independently predicted all-cause death at 30 days.

Conclusions:

  • Altered troponin levels in CKD patients indicate a high risk of coronary disease.
  • Peak hs-cTn levels, especially hs-cTnI, are valuable predictors of 30-day adverse events in CKD patients.
  • hs-cTnI demonstrates superior accuracy to hs-cTnT in this patient cohort.
Abstract

Keywords:
chronic kidney diseasecoronary artery diseasehigh sensitive troponin

More Related Videos

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

17.2K
Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

2.6K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.0K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
353
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
419
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
545
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
286
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
1.9K