Nutrient sensing pathways as therapeutic targets for healthy ageing
Anna Aiello1, Giulia Accardi1, Giuseppina Candore1
1a Department of Pathobiology and Medical Biotechnologies , University of Palermo , Palermo , Italy.
Expert Opinion on Therapeutic Targets
|March 11, 2017
Summary
This study explores anti-aging strategies targeting nutrient sensing pathways (NSPs) to promote healthy aging and delay age-related diseases. Modulating these pathways through dietary interventions shows promise for extending youthful, productive lives.
Area of Science:
- Gerontology
- Molecular Biology
- Nutritional Science
Background:
- Healthy aging is a major challenge due to increased lifespan without corresponding health improvements.
- Nutrient sensing pathways (NSPs) are increasingly recognized as key regulators of the aging process.
- Dietary interventions have demonstrated positive effects on aging via modulation of NSPs in various models.
Purpose of the Study:
- To review and discuss anti-aging strategies focused on NSPs.
- To explore therapeutic targets within NSPs for delaying aging and age-related diseases.
- To highlight approaches that modulate aging rates through NSPs.
Main Methods:
- Review of existing scientific literature on anti-aging strategies and NSPs.
- Analysis of studies demonstrating the impact of dietary interventions on NSPs.
- Synthesis of information on various approaches targeting NSPs.
Main Results:
- NSPs represent promising therapeutic targets for anti-aging interventions.
- Modulation of NSPs can influence the rate of aging.
- Dietary interventions are effective in modulating NSPs and impacting aging.
Conclusions:
- Targeting NSPs offers a viable strategy to slow the aging process.
- These strategies hold potential for extending healthy, productive lifespans.
- Further research into NSP modulation could lead to significant advancements in anti-aging therapies.
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