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Relationship between diffuse idiopathic skeletal hyperostosis, abdominal aortic calcification and associated

Emilio Pariente-Rodrigo1, Giusi Alessia Sgaramella2, José Manuel Olmos-Martínez3

  • 1Medicina de Familia, EAP Camargo-Interior, Servicio Cántabro de Salud-Observatorio de Salud Pública de Cantabria, Muriedas, Cantabria, España.

Medicina Clinica
|March 12, 2017
PubMed

Insights

Diffuse idiopathic skeletal hyperostosis (DISH) is not consistently associated with abdominal aortic calcification (AAC). However, DISH is linked to metabolic syndrome, age, BMI, and waist circumference in older males.

Area of Science:

  • Rheumatology
  • Cardiology
  • Geriatrics

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) and abdominal aortic calcification (AAC) are associated with increased cardiovascular risk.
  • Investigating the relationship between DISH, AAC, and metabolic disorders is crucial for understanding cardiovascular risk factors.

Purpose of the Study:

  • To analyze the potential relationship between Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Abdominal Aortic Calcification (AAC).
  • To examine the association between metabolic disorders and DISH in a male population aged 50 years and above.

Main Methods:

  • An analytic cross-sectional study was conducted on a population-based cohort of 987 males aged 50 years and older.
  • Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Abdominal Aortic Calcification (AAC) were assessed using plain x-ray images and established criteria (Resnick-Niwayama and AAC-24 scale).
  • Correlation analysis and multivariate regression were employed to investigate interactions between DISH and clinical covariates, including metabolic syndrome.

Main Results:

  • The prevalence of DISH was 21.6% and AAC was 58.7% among the study participants.
  • Subjects with DISH were older and more likely to have metabolic syndrome (MS) compared to those without DISH.
  • While a weak, age-dependent association between AAC and DISH was observed, it lost significance after age adjustment. DISH showed significant associations with age, BMI, waist circumference, and MS.

Conclusions:

  • The study did not establish a consistent association between Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Abdominal Aortic Calcification (AAC).
  • Diffuse Idiopathic Skeletal Hyperostosis (DISH) is significantly associated with metabolic syndrome, increased age, higher BMI, and larger waist circumference in older males.
  • These findings highlight the importance of metabolic factors in the development of DISH, independent of aortic calcification.
Abstract

Keywords:
Calcificación vascularCardiovascular diseasesDiffuse idiopathic skeletal hyperostosisEnfermedades cardiovascularesEpidemiologic studiesEstudios epidemiológicosHiperostosis esquelética idiopática difusaHombresMalesMetabolic cardiovascular syndromeSíndrome X metabólicoVascular calcification

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