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Related Concept Videos

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Dopamine, T cells and multiple sclerosis (MS).

Mia Levite1,2, Franca Marino3, Marco Cosentino3

  • 1School of Pharmacy, Faculty of Medicine, The Hebrew University, Ein Karem, 12065, Jerusalem, Israel. mial@ekmd.huji.ac.il.

Journal of Neural Transmission (Vienna, Austria : 1996)
|March 12, 2017
PubMed
Summary
This summary is machine-generated.

Dopamine significantly impacts T cells, influencing their function and activation. Dopamine receptor dysregulation in T cells is implicated in multiple sclerosis, suggesting potential therapeutic targets.

Keywords:
DopamineDopamine receptorsExperimental autoimmune encephalomyelitisMultiple sclerosisNeuroimmunologyNeuroimmunomodulationT cells

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Area of Science:

  • Neuroimmunology
  • Cellular Immunology
  • Pharmacology

Background:

  • Dopamine is a crucial neurotransmitter affecting the nervous system and peripheral organs via five dopamine receptors (DRs).
  • Dopamine exerts potent effects on DR-expressing immune cells, particularly T cells and dendritic cells.

Purpose of the Study:

  • To review the role of dopamine receptors, their effects, and production within T cells.
  • To explore the implications of dopaminergic dysregulation in T cells for diseases like multiple sclerosis (MS).

Main Methods:

  • Review of existing literature on dopamine's effects on T cells and DRs.
  • Analysis of evidence linking dopaminergic dysregulation in T cells to MS pathogenesis and treatment responses.

Main Results:

  • Dopamine modulates T cell functions such as adhesion, migration, and cytokine secretion, with context-dependent effects.
  • Dopamine activates effector T cells (Teffs) while suppressing regulatory T cells (Tregs), promoting Teff activation.
  • Dopaminergic dysregulation, including altered DR expression in T cells, is observed in MS patients.

Conclusions:

  • Dopamine receptors in T cells represent potential therapeutic targets for MS.
  • Understanding the direct effects of dopaminergic drugs on T cells is crucial for patient treatment to avoid immune side effects.