Related Experiment Video
Updated: Mar 6, 2026
10:52
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
6.5K
PFO and Migraine: Is There a Role for Closure?
Melissa Rayhill1, Rebecca Burch2,3
1Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.
Current Neurology and Neuroscience Reports
|March 12, 2017
Summary
Closing a patent foramen ovale (PFO) is not recommended for migraine prevention. While some patients may benefit, risks and negative trial results suggest caution for this PFO closure treatment.
Area of Science:
- Cardiology
- Neurology
- Medical Interventions
Background:
- Observational studies indicated potential migraine reduction after patent foramen ovale (PFO) closure for other reasons.
- Migraine with aura, in particular, was suggested to improve following PFO closure.
Purpose of the Study:
- To evaluate the efficacy of PFO closure as a preventive treatment for migraine.
- To assess the safety and effectiveness of PFO closure in reducing migraine frequency and severity.
Main Methods:
- Review of randomized clinical trials including MIST, PRIMA, and PREMIUM.
- Analysis of primary endpoints and subgroup analyses, particularly for migraine with aura.
- Consideration of procedure-related adverse events.
Main Results:
- The MIST, PRIMA, and PREMIUM trials did not meet their primary endpoints for migraine prevention.
- The PREMIUM trial indicated a potential reduction in headache days for the migraine with aura subgroup, pending full results.
- Procedure-related adverse events, some life-threatening, were reported in clinical trials.
Conclusions:
- Current evidence does not support offering PFO closure as a routine preventive treatment for migraine.
- PFO closure may offer some migraine improvement for patients undergoing the procedure for other medically indicated reasons.
- Further research into specific patient subgroups who might benefit from PFO closure is limited by recruitment challenges and procedural risks.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.5K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.5K
01:19Mitral Valve Prolapse III: Nursing Management
495
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
495
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:26Mitral Stenosis III: Medical Management
390
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
390