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Related Experiment Video

Updated: Mar 6, 2026

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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No. 342-Hepatitis B and Pregnancy.

Eliana Castillo1, Kellie Murphy2, Julie van Schalkwyk3

  • 1Calgary, AB.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|March 13, 2017
PubMed
Summary

Pregnant women with hepatitis B virus (HBV) infection require careful management to prevent perinatal transmission. This review outlines current evidence on HBV epidemiology, natural history, and treatment options for expectant mothers.

Keywords:
Hepatitis Bantiviral therapybreast-feedingchronic hepatitisimmuno-prophylaxispregnancyvertical transmissionviral load

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Hepatology

Background:

  • Hepatitis B virus (HBV) infection poses risks during pregnancy, including perinatal transmission to newborns.
  • Effective management strategies are crucial for both maternal health and infant outcomes.

Purpose of the Study:

  • To comprehensively review the epidemiology, natural history, evaluation, and treatment of hepatitis B virus infection in pregnant individuals.
  • To provide guidance for obstetric care providers on managing HBV in pregnancy and counseling patients on perinatal risks and available interventions.

Main Methods:

  • A systematic literature search was conducted across Medline, EMBASE, and CINAHL from 1966 to March 2016.
  • Included studies were systematic reviews, randomized controlled trials, controlled clinical trials, and observational studies.
  • Additional unpublished literature was identified through various health technology assessment websites, clinical trial registries, and medical society resources.

Main Results:

  • Key outcomes evaluated include optimal thresholds for antiviral treatment to prevent perinatal transmission.
  • The review also assessed management considerations for invasive procedures during pregnancy in women with HBV infection.
  • Evidence quality was assessed using the Canadian Task Force on Preventive Health Care criteria.

Conclusions:

  • This guideline provides a framework for the management of hepatitis B virus infection during pregnancy.
  • It aims to support obstetric care providers in making informed decisions regarding patient counseling and treatment strategies.
  • Recommendations will be reviewed periodically to incorporate new evidence and ensure updated guidance.