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Circulating interferon in the guinea pig infected with the XJ, prototype Junin virus strain
C B Dejean1, J R Oubiña, G Carballal
1Instituto Nacional de Microbiología, Dr. C.G. Malbrán Departamento Virus, Buenos Aires, Argentina.
Journal of Medical Virology
|January 1, 1988
Abstract:
The interferon (IFN) induction capacity of the XJ prototype strain of Junín virus (JV) was investigated in the guinea pig model. Circulating alpha IFN was detected in 50% of the animals from days 2 to 9 postinfection (pi) and in 100% at day 11 pi, when all animals were in the premortem stage. Individual levels ranged from 20 to 1,280 guinea pig IFN units (GPIFNU)/ml. A correlation between XJ strain virulence and IFN titers was recorded. A possible role of IFN as a pathogenic factor in the outcome of the disease is discussed.