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Updated: Mar 6, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Role of immune cells in obesity induced low grade inflammation and insulin resistance
Ambreen Asghar1, Nadeem Sheikh1
1Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore 54590, Pakistan.
Abstract:
The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ovarian disease and several types of cancers. Obesity is characterized by pro-inflammatory condition in which hypertrophied adipose tissue along with immune cells contribute to increase the level of pro-inflammatory cytokines. Immune cells are the key players in inducing low grade chronic inflammation in obesity and are main factor responsible for pathogenesis of insulin resistance resulting Type 2 diabetes. The current review is aimed to investigate the mechanism of pro-inflammatory responses and insulin resistance involving immune cells and their products in obesity.
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