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Survivin and gynaecological tumours

Dušan Braný1, Dana Dvorská1, Pavol Slávik2

  • 1BioMed Martin-Division of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovakia; Department of Gynaecology and Obstetrics, Jessenius Faculty of Medicine in Martin, Comenius University, Slovakia.

Pathology, Research and Practice
|March 14, 2017
PubMed

Insights

Survivin, a protein involved in cell division and apoptosis, is highly expressed in cancers, indicating poor prognosis. Targeting survivin presents a therapeutic challenge but holds potential for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Background:

  • Survivin is the smallest member of the Inhibitors of Apoptosis (IAP) protein family.
  • It plays roles beyond apoptosis inhibition, including mitosis regulation, angiogenesis promotion, and DNA repair.
  • High survivin expression is observed in fetal tissues and various cancers, contrasting with low levels in healthy adult tissues.

Purpose of the Study:

  • To summarize the known functions of survivin, focusing on its role in apoptosis inhibition and cell division.
  • To review survivin's implication in the development of gynecological tumors.
  • To reference existing survivin inhibitors and their impact on tumor growth regulation.

Main Methods:

  • Literature review and synthesis of existing research on survivin.
  • Analysis of survivin's involvement in cellular processes like apoptosis and mitosis.
  • Examination of survivin's correlation with cancer development, prognosis, and treatment resistance.

Main Results:

  • Elevated survivin levels are linked to poor cancer prognosis, increased recurrence rates, and resistance to chemotherapy and radiotherapy.
  • Survivin is significantly implicated in the initiation and progression of numerous cancer types.
  • Despite its significance, the development of effective survivin inhibitors and molecular therapies remains a challenge.

Conclusions:

  • Survivin is a crucial factor in cancer development and progression, making it a significant target for cancer therapy.
  • Understanding survivin's multifaceted roles is essential for developing novel therapeutic strategies.
  • Further research and development are needed to overcome challenges in creating effective survivin-targeted treatments, particularly for gynecological cancers.
Keywords:
ApoptosisBIRC5Cell deathGynaecological tumoursSurvivin

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