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International therapeutic guidelines for patients with HCV-related extrahepatic disorders. A multidisciplinary expert

Anna Linda Zignego1, Manuel Ramos-Casals2, Clodoveo Ferri3

  • 1Interdepartmental Center for Systemic Manifestations of Hepatitis Viruses (MaSVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Autoimmunity Reviews
|March 14, 2017
PubMed

Insights

Hepatitis C virus (HCV) causes liver and extrahepatic diseases. Eradicating the virus improves prognosis and reduces non-liver related deaths, necessitating updated management guidelines.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) is a hepatotropic and lymphotropic virus.
  • HCV infection leads to liver disease and various extrahepatic manifestations (HCV-EHMs), such as cryoglobulinemic vasculitis, lymphoma, and neurological, cardiovascular, endocrine-metabolic, or renal diseases.
  • HCV-EHMs significantly impact patient prognosis, and viral eradication is linked to reduced non-liver related mortality.

Purpose of the Study:

  • To provide international recommendations for the therapeutic management of HCV-EHMs.
  • To define criteria for using antiviral and other therapeutic approaches in the era of interferon-free treatments.
  • To outline strategies for managing patients with coexisting HCV clinical manifestations.

Main Methods:

  • Development of recommendations based on qualified expert experience.
  • Comprehensive review of specific scientific literature.
  • Focus on etiological (antiviral) therapies and established pathogenetic treatments.

Main Results:

  • HCV eradication significantly reduces non-liver related deaths.
  • A multidisciplinary approach is crucial for managing diverse HCV clinical manifestations.
  • Antiviral therapies and traditional pathogenetic treatments remain valuable in managing HCV-EHMs.

Conclusions:

  • Updated international recommendations are needed for managing HCV-EHMs.
  • Therapeutic strategies should prioritize viral eradication and address specific manifestations.
  • Expert consensus and literature review guide the proposed management approaches for HCV-EHMs.

Keywords:
Anti-HCV therapyExtrahepatic manifestations of HCVHepatitis C virus (HCV)Non-etiological therapy

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